Cytomegalovirus (CMV) is a member of the Herpes virus family. Infections are usually mild and asymptomatic but may pose a significant medical risk in pregnant women, new borns and immunocompromised individuals. In utero infection can lead to varying degrees of mental retardation, chorioretinitis, hearing loss and neurologic problems. Since the risk of in utero transmission and CMV related damage to the fetus is highly likely during primary infection, reliable recognition of primary infection is of high importance in pregnant women. It is recommended to test for CMV IgG and CMV IgG avidity to exclude primary infection. Positive CMV IgM in association with low CMV IgG avidity is a strong indicator of primary infection within the last 4 months