Primary post natal Rubella virus infection is typically self limiting mild disease characterized by maculopapular rash, fever, malaise and lymphadenopathy. Primary prenatal infections may have devastating effects leading to Congenital Rubella Syndrome (CRS) in the neonates. This syndrome includes low birth weight, cataract, deafness, congenital heart disease and mental retardation. A positive Rubella IgG antibody indicates successful immunization or past exposure. The result of a single antibody determination should not be used to diagnose recent infection. Acute and convalescent sera should be collected 2-4 weeks apart and a rising titer of more than 30% is considered significant.