Anticardiolipin antibodies(ACA) belong to the group of Antiphospholipid antibodies which are positive in 30-40% cases of Systemic lupus erythematosus and also in patients with other Rheumatic diseases. Presence of cardiolipin antibodies is considered to be of significant diagnostic relevance in cases of Venous/Arterial thrombosis, Thrombocytopenia, Livedo reticularis, Habitual abortions and Neurological manifestations. Elevated ACA levels are also seen in patients with Cardiovascular insufficiency and Myocardial infarction