Test
C3 & C4 Complement Panel
Pathology
Summary
Complement proteins are components of innate immune system that activate the pathways thereby generating peptides which are necessary to clear immune complexes and generate lytic activity. C3 & C4 complement deficiencies show increased susceptibilities to infections and may play a role as an etiologic agent in the development of Autoimmune disease. Increased Levels – Acute phase response due to inflammation, trauma & tissue necrosis, Biliary obstruction & Focal glomerulosclerosis Decreased Levels – Infancy, Genetic deficiency, Acquired deficiency like Lupus nephritis, Collagen vascular diseases, severe infections, SLE, Angioedema, Autoimmune hemolytic anemia & Autoimmune nephritis
