Anti- HBc IgM is the earliest specific antibody appearing usually within 2 weeks after HBsAg. It is found in high titres for a short period during the acute phase that covers the serologic window and declines to low levels during recovery. It may be detectable upto 6 months. It may be the only serologic marker present after HBsAg and HBeAg have disappeared and HBsAb & HBeAb have not appeared ( Serologic gap / window).