Hepatitis E Virus (HEV) is an unenveloped RNA virus which accounts for sporadic and epidemic hepatitis in tropical and semi-tropical countries and in people returning from these areas. Similar to HAV, it is enterically transmitted, has a self limiting course and is not associated with chronicity. Infection with HEV has a virulent course in late pregnancy with mortality ranging from 20-25%. HEV IgM antibody is detected 1-4 weeks post infection.