Herpes simplex virus (HSV) belongs to the family Herpesviridae. HSV infections occur worldwide with no seasonal distribution. The prevalence of HSV-1 infection increases gradually from childhood, reaching 80% or more in later years whereas the prevalence of HSV-2 infection remains low until adolescence and the onset of sexual activity. A large percentage of individuals seropositive for HSV are unaware of the infection, thereby comprising an important reservoir of infection. HSV-1 infections are characterized by oral lesions like gingivostomatitis & pharyngitis. Proportion of primary genital infections due to HSV-1 is increasing the world over due to changing sexual practices including increased oral genital exposure. HSV-2 infections are found principally in genitalia and transmitted through sexual contact. Primary infection with HSV-2 classically presents as Herpes genitalis.