IgA accounts for 13% of total immunoglobulins and protects the skin & mucosa against microorganisms. It is capable of binding toxins & in combination with Lysozyme develops anti-bacterial and anti-viral activities. IgA is the predominant immunoglobulin in body secretions like saliva, sweat and colostrum. Polyclonal IgA increase is seen in Chronic liver diseases, Chronic infections, Autoimmune disorders, Sarcoidosis and Wiscott- Aldrich syndrome. Monoclonal IgA increase is seen in IgA Myeloma. Decreased synthesis of IgA is found in Congenital and Acquired Immunodeficiency diseases. Decreased IgA levels are seen in Protein losing enteropathies and skin burns.